C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 65/28 (2006.01) A61K 8/31 (2006.01) A61K 8/33 (2006.01) A61K 8/35 (2006.01) A61K 8/36 (2006.01) A61K 8/39 (2006.01) A61K 8/44 (2006.01) A61K 8/46 (2006.01) A61K 8/49 (2006.01) A61K 8/60 (2006.01) A61K 8/64 (2006.01) A61K 31/165 (2006.01) A61K 31/19 (2006.01) A61K 31/235 (2006.01) A61K 31/34 (2006.01) A61K 31/35 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/535 (2006.01) A61K 31/70 (2006.01) A61Q 5/00 (2006.01) A61Q 19/00 (2006.01) A61Q 19/02 (2006.01) A61Q 19/10 (2006.01) C07C 65/19 (200
Patent
CA 2263362
The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), (b) or (c); Z being O or S, R1 is -CH3, -CH2-O-R6, -OR6 or -COR7; R2 is -OR8, -SR8 or a polyether radical if in the latter case R4 is C1-C20 alkyl and is in ortho or meta position relative to X-Ar; R3 is alkyl or R2 and R3 together form a cycle optionally interrupted by O or S; R4 is H, halogen, C1-C20 alkyl, -OR8, a polyether or aryl radical; R5 is H, halogen, C1-C20 alkyl or -OR8; R6 is H, alkyl or -COR9; R7 is H, alkyl, -N(r')(r") or -OR10; R8 is H, alkyl or -COR9; R9 is alkyl; R10 is H, C1-C20 alkyl, alkenyl, monohydroxyalkyl or polyhydroxyalkyl, aryl or aralkyl or a sugar residue, r' and r'' are H, alkyl, mono- or polyhydroxyalkyl, aryl, an amino acid or sugar residue or together form a heterocycle, X represents a radical of formula (d) or (e) in which R11 is H or -OR6; R12 is H or alkyl; or R11 and R12 form an oxo radical, and the salts, optical and geometrical isomers of the compounds of formula (I).
Composés bi-aromatiques répondant à la formule (I): Ar representant (a), (b) ou (c); Z étant O ou S, R1 est -CH3, -CH2-O-R6, -OR6 ou -COR7; R2 est -OR8, -SR8 ou un radical polyéther si dans ce dernier cas R4 est C1-C20 alkyle et est en ortho ou méta par rapport à X-Ar; R3 est alkyle ou R2 ou R3 ensemble forment un cycle éventuellement interrompu par O ou S; R4 est H, halogène, C1-C20 alkyle, -OR8, un radical polyéther ou aryle; R5 est H, halogène, C1-C20 alkyle ou - OR8; R6 est H, alkyle ou -COR9; R7 est H, alkyle, -N(r')(r") ou -OR10; R8 est H, alkyle ou -COR9; R9 est alkyle; R10 est H, C1-C20 alkyle, alkényle, mono- ou polyhydroxyalkyle, aryle ou aralkyle ou un reste de sucre, r' et r" sont H, alkyle, mono- ou polyhydroxyalkyle, aryle, un reste d'aminoacide ou de sucre ou ensemble forment un hétérocycle, X représente un radical de formule (d) ou (e); R11 étant H ou - OR6; R12 est H ou alkyle, ou R11 et R12 forment un radical oxo, et les sels, isomères optiques et géométriques des composés de formule (I).
Bernardon Jean-Michel
Trouille Simon
Galderma Research & Development
Robic
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