Bi-aromatic compounds bound by a heteroethynylene radical...

Details Bi-aromatic compounds bound by a heteroethynylene radical... Bi-aromatic compounds bound by a heteroethynylene radical...

C - Chemistry, Metallurgy

07

C

C07C 323/62 (2006.01) A61K 31/095 (2006.01) A61K 31/19 (2006.01) A61K 31/235 (2006.01) A61K 31/44 (2006.01) C07C 317/44 (2006.01) C07C 323/56 (2006.01) C07C 391/02 (2006.01) C07D 213/79 (2006.01) C07D 213/80 (2006.01) C07D 213/82 (2006.01) C07D 335/06 (2006.01)

Patent

CA 2268796

The invention concerns compounds of formula (I) in which: Ar represents a radical selected among formulae (a) to (c). Z being O, S, or N-R6; R1 represents in particular a halogen atom, -CH3, or carboxyl; R2 and R3 represent in particular H, alkyl, cycloalkyl; or R2 and R3 together form a cycle with 5 or 6 chains; R4 and R5 represent in particular H or a halogen atom; R6 represents in particular H or alkyl; X represents a radical Y-CC-; Y represents O, S(O)n or Se(O)n', n being 0, 1 or 2, and the salts of the compounds of formula (I). Said compounds can be used in particular for treating dermatological diseases related to keratinization disorder, and to fight against skin ageing.

Composés de formule (I), dans laquelle: Ar représente un radical choisi parmi les formules (a) à (c) suivantes. Z étant O ou S, ou N-R6; R1 représente notamment un atome d'halogène, -CH3, ou carboxyle; R2 et R3 représentent notamment H, alkyle, cycloalkyle; ou R2 et R3, pris ensemble forment un cycle à 5 ou 6 chaînons; R4 et R5 représentent notamment H ou un atome d'halogène; R6 représente notamment H ou alkyle; X représente un radical -Y-C.ident.C-, Y représentant O, S(O)n ou Se(O)n'; n étant 0, 1 ou 2; et les sels des composés de formule (I). Ces composés sont utilisables notamment dans le traitement des affections dermatologiques liées à un désordre de la kératinisation, et pour lutter contre le vieillissement de la peau.

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