Bi-aryl aminotetralines

Details Bi-aryl aminotetralines Bi-aryl aminotetralines

C - Chemistry, Metallurgy

07

C

C07C 311/20 (2006.01) A61K 31/18 (2006.01) A61K 31/395 (2006.01) A61P 11/00 (2006.01) C07C 311/29 (2006.01) C07C 323/67 (2006.01) C07D 213/34 (2006.01) C07D 213/71 (2006.01)

Patent

CA 2735392

The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein R1-R5, A, B, Q, W, and X are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and us-ing the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formu-la (I) are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

L'invention concerne des composés de la formule (I) et des sels et des esters de qualité pharmaceutique de ceux-ci, R1-R5, A, B, Q, W et X étant définis dans la description et les revendications détaillées. De plus, la présente invention concerne des procédés de fabrication et d'utilisation des composés de la formule (I), ainsi que des compositions pharmaceutiques contenant de tels composés. Les composés de la formule (I) sont des antagonistes du récepteur CRTH2 et peuvent sutiliser dans le traitement de maladies et de troubles associés à ce récepteur, tels que l'asthme.

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