Bi-cyclic pyrimidine inhibitors of tgf.beta.

Details Bi-cyclic pyrimidine inhibitors of tgf.beta. Bi-cyclic pyrimidine inhibitors of tgf.beta.

C - Chemistry, Metallurgy

07

D

C07D 239/70 (2006.01) C07D 487/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2520465

Compounds in which a pyrimidine nucleus is bridged at the (5) and (6) position and are further substituted at positions (2) and (4) with substituents comprising aromatic moieties are useful in treating subjects with conditions ameliorated by inhibition of TGF.beta. activity.

L'invention concerne des composés dans lesquels un noyau pyrimidine est ponté au niveau des positions (5) et (6), substitués au niveau des positions (2) et (4) au moyen de substituants comprenant des fractions aromatiques et utiles pour le traitement de sujets dont les états sont améliorés par inhibition de l'activité de TGF.beta..

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