C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/00 (2006.01) A61K 31/138 (2006.01) A61K 31/4535 (2006.01) A61K 38/08 (2006.01) A61K 38/16 (2006.01) A61P 27/02 (2006.01) A61P 35/00 (2006.01) C07K 5/083 (2006.01) C07K 7/06 (2006.01) C12N 9/12 (2006.01)
Patent
CA 2695384
The present invention provides compound having the general structure A or pharmaceutically acceptable salts thereof: Het-L-P (A) wherein Het is an aromatic moiety comprising a heterocyclic structure mimicking ATP, P is a docking site derived peptide or a docking site peptide mimetic, and L is a linking moiety, wherein L links the ATP mimetic to the docking site peptide moiety. The compounds having the general structure A can serve as inhibitors of kinases, such as the kinases JNK, Erk and P38.
L'invention concerne un composé ayant la structure générale A ou les sels pharmaceutiquement acceptables de celui-ci : Het-L-P (A) où Het est une fraction aromatique comprenant une structure hétérocyclique imitant ATP, P est un peptide dérivé d'un site de liaison ou un mimétique de peptide de site de liaison, et L est une fraction de liaison, où L lie le mimétique d'ATP à la fraction de peptide de site de liaison. Les composés ayant la structure générale A peuvent servir d'inhibiteurs de kinase, telles que les kinases JNK, Erk et P38.
Burnham Institute For Medical Research
Mbm Intellectual Property Law Llp
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