C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A01K 67/027 (2006.01) A61K 45/00 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01) C40B 40/06 (2006.01)
Patent
CA 2362586
The invention provides polynucleotides including biallelic markers derived from genes involved in arachidonic acid metabolism and from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.
L'invention concerne des polynucléotides comportant des marqueurs biallèles dérivés de gènes qui interviennent dans le métabolisme de l'acide arachidonique et de régions génomiques flanquant les gènes en question. L'invention concerne également des amorces capables d'hybridation avec les régions flanquant ces marqueurs biallèles. L'invention concerne en outre des polynucléotides et des procédés appropriés pour le génotypage d'un échantillon contenant un acide nucléique pour un ou plusieurs marqueurs biallèles décrits. Enfin, l'invention concerne des procédés de détection d'une corrélation statistique entre un allèle de marqueur biallèle et un phénotype et/ou entre un haplotype de marqueur biallèle et un phénotype.
Blumenfeld Marta
Bougueleret Lydie
Chumakov Ilya
Genset S.a.
Serono Genetics Institute S.a.
Sim & Mcburney
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