C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2395240
The invention provides polynucleotides including biallelic markers derived from genes involved in CNS disorders and from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.
L'invention concerne des polynucléotides comprenant des marqueurs biallèles dérivés des gènes responsables de troubles du SNC et des régions génomiques flanquant ces gènes. Elle concerne aussi les amorces s'hybridant aux régions flanquant ces marqueurs biallèles. L'invention se rapporte également à des polynucléotides et des procédés pour génotyper un acide nucléique contenant un échantillon pour un ou plusieurs marqueurs biallèles de l'invention. En outre, l'invention concerne des procédés pour détecter une corrélation statistique entre un allèle de marqueurs biallèles et un phénotype et/ou entre un haplotype de marqueurs biallèles et un phénotype.
Blumenfeld Marta
Chu Tom
Cohen Daniel
Genset S.a.
Serono Genetics Institute S.a.
Sim & Mcburney
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