C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A01K 67/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2363551
The invention provides polynucleotides including biallelic markers derived from genes involved in the biotransformation of xenobiotics such as drugs and from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.
L'invention porte sur des polynucléotides comprenant des marqueurs bialléliques dérivés de gènes impliqués dans la biotransformation de xénobiotiques tels que des médicaments, et dérivés de régions génomiques situées à côté de ces gènes. L'invention porte également sur des polynucléotides et sur des procédés appropriés pour réaliser le génotype d'un échantillon contenant un acide nucléique destiné à un ou plusieurs marqueurs bialléliques de l'invention. Cette invention porte également sur un procédé de détection d'une corrélation statistique entre un allèle de marqueur biallélique et un phénotype et/ou entre un haplotype de marqueur biallélique et un phénotype.
Blumenfeld Marta
Bougueleret Lydie
Chumakov Ilya
Cohen-Akenine Annick
Genset S.a.
Serono Genetics Institute S.a.
Sim & Mcburney
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