Biaryl benzoimidazole derivatives and pharmaceutical...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/14 (2006.01)

Patent

CA 2656810

The biaryl benzoimidazole derivative of the present invention has an excellent inhibitory effect on calcium influx in HEK cells, thereby showing a powerful antagonistic effect on a vanilloid receptor, and further has an excellent analgesic effect, thereby being useful for preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, irritable bowel syndrome, a respiratory disorder such as cough, asthma, and chronic obstructive pulmonary disease, burning, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

Le dérivé de biaryle benzoimidazole selon la présente invention présente un excellent effet inhibiteur sur l'influx calcique dans les cellules HEK, ce qui indique ainsi un effet antagoniste puissant sur un récepteur vanilloïde et présente également un excellent effet analgésique, ce qui le rend par conséquent utile pour prévenir ou traiter la douleur, la douleur aigüe, la douleur neuropathique, la douleur post-opératoire, la migraine, l'arthralgie, les neuropathies, les lésions nerveuses, la neuropathie diabétique, la maladie neurologique, la névrodermite, l'accident vasculaire, l'hypersensibilité de la vessie, le syndrome du côlon irritable, un trouble respiratoire tel que la toux, l'asthme et la maladie pulmonaire obstructive chronique, les brûlures, le psoriasis, les démangeaisons, les vomissements, l'irritation de la peau, des yeux et des membranes des muqueuses, les ulcères de l'estomac et du duodénum, les maladies intestinales inflammatoires et les maladies inflammatoires.

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