C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/08 (2006.01) A61K 31/165 (2006.01) A61K 31/40 (2006.01) A61K 31/535 (2006.01) A61P 17/14 (2006.01) A61Q 7/00 (2006.01) C07C 215/74 (2006.01) C07C 217/82 (2006.01) C07C 233/25 (2006.01) C07C 233/29 (2006.01) C07C 233/33 (2006.01) C07C 233/76 (2006.01) C07D 295/096 (2006.01) C07D 295/112 (2006.01)
Patent
CA 2375674
The present disclosure describes novel compounds and compositions which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The compounds have a biphenyl structure as described in formula (I) and are preferably cardiac- sparing, and pharmaceutically acceptable salts, hydrates and biohydrolyzable amides, esters, and imides thereof, wherein, R1, R2, R3, R4, R5, R6, R6', R7, R8, R9, R10, Y, X, R11, and R12 are defined herein.
La présente invention concerne de nouveaux composés et de nouvelles compositions particulièrement utiles pour traiter la décalvation chez les mammifères, et notamment pour interrompre et/ou inverser ce processus et favoriser la pousse des cheveux. Ces composés présentent une structure biphényle de formule (I), et produisent de préférence un effet d'épargne cardiaque. Cette invention concerne également des sels pharmaceutiquement acceptables, des hydrates, et des amides, des esters et des imides biohydrolysables de ceux-ci. Dans la structure susmentionnée, R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, R¿6'?, R¿7?, R¿8?, R¿9?, R¿10?, Y, X, R¿11? et R¿12? sont tels que définis dans la description.
Mciver John Mcmillan
Youngquist Robert Scott
Smart & Biggar
The University Of Texas Southwestern Medical Center
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