Biaryl compounds as serine protease inhibitors

Details Biaryl compounds as serine protease inhibitors Biaryl compounds as serine protease inhibitors

C - Chemistry, Metallurgy

07

C

C07C 229/38 (2006.01) A61K 31/155 (2006.01) A61K 31/192 (2006.01) A61K 31/24 (2006.01) A61K 31/255 (2006.01) A61K 31/27 (2006.01) A61K 31/34 (2006.01) A61K 31/341 (2006.01) A61K 31/38 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61K 31/4418 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) A61K 31/69 (2006.01) C07C 63/04 (2006.01) C07C 233/54 (2006.01) C07C 235/84 (2

Patent

CA 2426430

Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as anticoagulating agents.

La présente invention concerne des composés représentés par la formule (I) qui conviennent comme inhibiteurs de trypsine comme les enzymes sérine protéases telles que la thrombine, le facteur VIIa, le facteur Xa, TF/FVIIa et la trypsine. Ces composés peuvent convenir pour traiter et/ou pour prévenir des troubles de la coagulation, et comme agents anticoagulants.

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