Biaryl-oxa(thia)zole derivatives and their use as ppars...

Details Biaryl-oxa(thia)zole derivatives and their use as ppars... Biaryl-oxa(thia)zole derivatives and their use as ppars...

C - Chemistry, Metallurgy

07

D

C07D 263/32 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) C07D 277/24 (2006.01) C07D 413/10 (2006.01)

Patent

CA 2382966

Compounds represented by Formula (I) wherein n is 2, 3, or 4; V is O or S; W is O, S, or SO2 and at least one R5 is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; are modulators of peroxisome proliferator activated receptors and are useful in the treatment of type II diabetes and of cardiovascular diseases.

La présente invention concerne des composés représentés par la formule (I) dans laquelle n est égal à 2, 3, ou 4, V représente O ou S, W représente O, S, ou SO¿2? et au moins un R¿5? représente un aryle ou un hétéroaryle substitué ou non substitué. Lesdits composés sont des modulateurs des récepteurs activés de la prolifération des peroxysomes (PPAR) et sont utiles dans le traitement du diabète de type II et des maladies cardio-vasculaires.

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