Biaryl substituted pyrazoles as sodium channel blockers

Details Biaryl substituted pyrazoles as sodium channel blockers Biaryl substituted pyrazoles as sodium channel blockers

C - Chemistry, Metallurgy

07

D

C07D 231/14 (2006.01)

Patent

CA 2520804

Biaryl substituted pyrazole compounds are sodium channel blockers useful for the treatment of pain and other conditions. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treatment of conditions, including acute pain, chronic pain, visceral pain, inflammatory pain, and neuropathic pain, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more therapeutically active compounds.

L'invention concerne des composés de pyrazoles biaryle substitué utilisé en tant que bloqueurs de canaux sodiques dans le traitement de douleurs et d'autres états. Les compositions pharmaceutiques de l'invention contiennent une quantité efficace de ces composés soit seul, soit en combinaison avec un ou plusieurs composés actifs sur le plan thérapeutique, et un support acceptable sur le plan pharmaceutique. Les procédés de traitement d'états, tels que les douleurs aiguës, les douleurs chroniques, les douleurs inflammatoires et les douleurs neuropathiques, consistent à administrer une quantité efficace de ces composés soit seul, soit en combinaison avec des composés actifs sur le plan thérapeutique.

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