Biaryl substituted thiazoles, oxazoles and imidazoles as...

C - Chemistry – Metallurgy – 07 – D

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C07D 277/42 (2006.01) C07D 277/56 (2006.01)

Patent

CA 2522476

Biaryl substituted thiazole, oxazole and imidazole compounds are sodium channel blockers useful for the treatment of pain. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treatment or prevention of conditions, including acute pain, chronic pain, visceral pain, inflammatory pain, and neuropathic pain comprise administering an effective amount of the present compounds, either alone, or in combination with one or more therapeutically active compounds.

L'invention concerne des composés de thiazole, d'oxazole et d'imidazole à substitution biaryle, qui sont des bloqueurs du canal sodique qui conviennent pour le traitement de la douleur. L'invention concerne également des compositions pharmaceutiques contenant une dose efficace de ces composés, soit seuls, soit combinés avec un ou plusieurs composés présentant une activité thérapeutique, et un excipient pharmaceutiquement acceptable. L'invention concerne en outre des méthodes permettant le traitement ou la prévention de pathologies comprenant la douleur aiguë, la douleur chronique, la douleur viscérale, la douleur inflammatoire et la douleur neuropathique, consistant à administrer une dose efficace des composés décrits, soit seuls, soit combinés à un ou plusieurs composés présentant une activité thérapeutique

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