Biaryl sulfonamides and methods for using same

Details Biaryl sulfonamides and methods for using same Biaryl sulfonamides and methods for using same

C - Chemistry, Metallurgy

07

D

C07D 215/22 (2006.01) A61K 31/198 (2006.01) A61K 31/33 (2006.01) C07C 311/29 (2006.01) C07C 311/46 (2006.01) C07D 213/30 (2006.01) C07D 213/64 (2006.01) C07D 215/14 (2006.01) C07D 295/08 (2006.01) C07D 295/18 (2006.01) C07D 319/18 (2006.01)

Patent

CA 2548513

The present invention relates to biaryl sulfonamides of the formula 1: wherein: R1 is H or Cl-.C6 a]kyl; R2 is H, C I -C6 alkyl, (CH2)nR2' , phenyl, or benzyl; n is 0-6; R2'is aryl, heteroaryl, cycloalkyl, or heterocycloalkyl; R 3 is, independently with respect to each occurrence, H, halogen, OC(halogen)3,C(halogen)3, alkoxy, or C I -C 6 alkyl; X is selected from CH20, OCH2, C (R3)=(R3)2-C(R3)2, CH2NHC(=O), O(C=O)NH, O, C(=O)CH2, SO2CH2C(=O)NH, SO2NH, OC(=O), CH2S(O), and CH2S(O)2; and Z is at least one aryl or heteroaryl moiety, and their use as for example metalloproteinase inhibitors.

L'invention concerne des sulfonamides de biaryle de formule 1. R?1¿ est H ou alkyle Cl-.C6; R?2¿ est H, alkyle CI -C6, (CH¿2?)¿n?R?2'¿, phényle, ou benzyle; n vaut de 0 à 6; R?2'¿est aryle, hétéroaryle, cycloalkyle, ou hétérocycloalkyle; R ?3¿ est, indépendamment de chaque occurrence, H, halogène, OC(halogène)¿3?,C(halogène)¿3?, alcoxy, ou alkyle CI -C6; X peut être CH¿2?0, OCH¿2?, C (R?3¿)=(R?3¿)¿2?-C(R?3¿)¿2?, CH¿2?NHC(=O), O(C=O)NH, O, C(=O)CH¿2?, SO¿2?CH¿2?C(=O)NH, SO¿2?NH, OC(=O), CH¿2?S(O), et CH¿2?S(O)¿2?; et Z est au moins une fraction aryle ou hétéroaryle. L'invention concerne également l'utilisation des ces produits comme inhibiteurs de métalloprotéinase, par exemple.

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