C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/165 (2006.01) A61K 45/06 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2517088
The present invention discloses compounds which are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In other aspects, the invention is directed to pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes. Compounds of the invention generally have the structure: F (1) where the substituents are as defined herein.
La présente invention concerne des composés se présentant sous la forme de nouveaux antagonistes pour l'hormone de concentration de la mélanine (MCH), ainsi que des procédés de préparation de ces composés. Dans d'autres aspects, l'invention concerne des compositions pharmaceutiques comprenant des antagonistes de la MCH ainsi que des méthodes d'utilisation de ces compositions pour traiter l'obésité, les troubles métaboliques, les troubles de l'alimentation tels que l'hyperphagie et le diabète. Les composés de l'invention présentent généralement la structure (1), dans laquelle les substituants sont tels que définis dans la description.
Burnett Duane A.
Qiang Li
Sasikumar Thavalakulamgara K.
Wu Wen-Lian
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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