Biciclic cyclohexylamines and their use as nmda receptor...

Details Biciclic cyclohexylamines and their use as nmda receptor... Biciclic cyclohexylamines and their use as nmda receptor...

C - Chemistry, Metallurgy

07

D

C07D 263/58 (2006.01) A61K 31/4184 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61P 25/16 (2006.01) C07D 235/26 (2006.01) C07D 277/68 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2409006

Described are bicycle-substituted cyclohexylamines of Formula (I) and their pharmaceutically acceptable salts thereof. The compounds are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, cerebral ischemia, cardiac arrest, stroke, and Parkinson's disease. The substituents are defined in the specification.

Cette invention a trait à des cyclohexylamines à substitution bicyclique correspondant à la formule (I) ainsi qu'à leurs sels acceptables du point de vue pharmaceutique. Ces composés sont des antagonistes de complexes du canal du récepteur de NMDA, des plus utiles pour traiter des troubles vasculaires cérébraux, notamment, l'ischémie cérébrale, l'arrêt cardiaque, l'accident vasculaire cérébral ainsi que la maladie de Parkinson. Les substituants sont définis dans le descriptif.

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