Bicyclic [3.1.0] heteroaryl amides as type i glycine...

Details Bicyclic [3.1.0] heteroaryl amides as type i glycine... Bicyclic [3.1.0] heteroaryl amides as type i glycine...

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4178 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61P 25/00 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2603939

The present invention relates to a series of substituted bicyclic[3.1.0] heteroaryl amides of the Formula I, wherein A, Q, X, Y, Z and R1-R5 groups are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.

L'invention concerne une série d'hétéroarylamides bicycliques [3.1.0] de la formule I, dans laquelle A, Q, X, Y, Z et les groupes R1-R5 sont tels que définis dans le descriptif, qui présentent une activité d'inhibiteurs de transport de la glycine, leurs sels pharmaceutiquement acceptables, les compositions pharmaceutiques les renfermant, et leur utilisation visant l'amélioration des facultés cognitives et le traitement des symptômes positifs et négatifs de la schizophrénie et d'autres psychoses chez les mammifères, notamment les humains.

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