Bicyclic amide derivatives and their use as muscle relaxants

Details Bicyclic amide derivatives and their use as muscle relaxants Bicyclic amide derivatives and their use as muscle relaxants

C - Chemistry, Metallurgy

07

C

C07C 233/11 (2006.01) A61K 31/165 (2006.01) A61K 31/353 (2006.01) A61K 31/5375 (2006.01) A61P 21/02 (2006.01) A61P 25/08 (2006.01) A61P 25/22 (2006.01) A61P 29/00 (2006.01) C07C 235/34 (2006.01) C07D 295/185 (2006.01) C07D 311/58 (2006.01)

Patent

CA 2355987

-49- Novel compounds of formula (I): Image wherein R1, R2, R3 and R4 are each selected from hydrogen and fluoro and at least one and not more than two is fluoro; R5 is selected from hydrogen and C1-C4 alkyl; R6 is selected from hydrogen, C1-C4 alkyl and hydroxy; R7 is selected from hydrogen and hydroxy; R8 and R9 are each selected from hydrogen, C1,-C4 alkyl and cyclo (C3 or C4) alkyl or together with the nitrogen form a morpholino group; and X is selected from methylene and -O- and is always -O- when any of R5, R6 and R7 is other than hydrogen; and a salt or solvate thereof; have a number of uses in medicine in particular as central muscle relaxants.

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