Bicyclic amidine derivatives as inhibitors of nitric oxide...

Details Bicyclic amidine derivatives as inhibitors of nitric oxide... Bicyclic amidine derivatives as inhibitors of nitric oxide...

C - Chemistry, Metallurgy

07

D

C07D 333/38 (2006.01) A61K 31/33 (2006.01) C07D 207/34 (2006.01) C07D 307/68 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2188680

There are provided compounds of formula (I), wherein D represents a five membered heterocyclic aromatic ring containing 1 to 4 heteroatoms selected from O, N or S, optionally substituted at a carbon atom by halogen, trifluoromethyl, alkyl C1 to 6, nitro or cyano, and which is connected to the remainder of the compound of formula (I) through a carbon atom; A represents N(X) or CH(-(CH2)m-NXY); U represents NH, O or CH2; V represents (CH2)a; W represents (CH2)b; a, b, m, X and Y are as defined in the specification, together with processes for their preparation and compositions containing them. Compounds of formula (I) are nitric oxide synthetase inhibitors and are useful in therapy.

L'invention concerne des composés de la formule (I). Dans cette formule, D représente un noyau aromatique hétérocyclique à cinq éléments contenant 1 à 4 hétéroatomes choisis parmi 0, N ou S, éventuelle substitué sur un atome de carbone par halogène, trifluorométhyle, alkyle en C1 à C6, nitro ou un cyano, et est relié au reste du composé de la formule (I) par l'intermédiaire d'un atome de carbone; A représente N(X) ou CH(-(CH¿2?)¿m?NXY; U représente NH, O ou CH¿2?; V représente (CH¿2?)¿n?; W représente (CH¿2?)¿b?; a, b, m, X et Y sont comme défini dans la description. L'invention concerne également des procédés de préparation de ces composés et des formulation les contenant. Les composés de la formule (I) sont les inhibiteurs de la synthétase de l'oxyde nitrique et sont utiles dans des thérapies.

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