Bicyclic amino acids

Details Bicyclic amino acids Bicyclic amino acids

C - Chemistry, Metallurgy

07

D

C07D 265/36 (2006.01) A61K 31/335 (2006.01) A61K 31/535 (2006.01) C07D 319/20 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2280727

The invention relates to compounds of formula (1), wherein X, Y, Z, R1, R2, R3, R4, R5, R7, R8, R11, m and n have the meaning cited in Claim 1, and to their physiologically acceptable salts. Said compounds can be used as integrin inhibitors, specially for prophylaxis and treatment of circulatory diseases, thrombosis, infarcts, coronary heart diseases, arteriosclerosis, osteoporosis, pathological symptoms sustained or propagated by angiogenesis and in tumor therapy.

L'invention concerne des composés de la formule (I) dans laquelle X, Y, Z, R<1>, R<2>, R<3>, R<4>, R<5>, R<7>, R<8>, R<11>, m et n ont la signification mentionnée dans la revendication 1. L'invention concerne également leurs sels physiologiquement tolérables. Ces aminoacides aromatiques bicycliques s'utilisent comme inhibiteurs de l'intégrine, notamment dans le cadre de la prophylaxie et du traitement de maladies de la circulation, en cas de thrombose, d'infarctus, de maladies cardiaques coronariennes, d'artériosclérose, d'ostéoporose, dans le cas de symptômes pathologiques entretenus ou propagés par angiogenèse et dans le cadre de la thérapie de tumeurs.

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