C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/20 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) A61K 31/557 (2006.01) A61K 31/66 (2006.01) C07C 233/52 (2006.01) C07C 233/63 (2006.01) C07C 233/74 (2006.01) C07C 233/81 (2006.01) C07C 233/84 (2006.01) C07C 235/22 (2006.01) C07C 235/36 (2006.01) C07C 235/42 (2006.01) C07C 235/54 (2006.01) C07C 235/84 (2006.01) C07C 237/38 (2006.01) C07C 237/42 (2006.01) C07C 245/08 (2006.01) C07C 251/48 (2006.01) C07C 251/86 (2006.01) C07C 255/57 (2006.01) C07C 271/24 (2006.01) C07C 275
Patent
CA 2225250
The present invention is directed to a compound of the formula (I) Image wherein Image for example, a compound below: Image wherein R1 is CH3, H or Na; and X1-X2-X3 is Image or its salt or a hydrate thereof. Such a compound is useful as PGD2 antagonist and can be used as a drug for treating diseases in which mast cell dysfunction is involved, for example, systemic mastocytosis and disorders of systemic mast cell activation, and also tracheal contraction, asthma, allergic rhinitis, allergic conjunctivitis, urticaria, injury due to ischemic reperfusion, and as an anti-inflammatory agent. It is particularly useful in the treatment of nasal occlusion.
Cette invention concerne des composés, ainsi que leurs sels et leurs hydrates, qui correspondent à la formule générale (I) où (a) représente (b) ou (c). On peut citer à titre d'exemple, les composés (d) et (e), lesquels sont utiles en qualité d'antagoniste de PGD2 et peuvent ainsi être utilisés, par exemple, dans la composition de remèdes contre la mastocytose systémique ou les troubles d'activation de mastocytes systémiques, de médicament contre la brochoconstriction, d'antiasthmatique, de médicament contre l'agent de la rhinite allergique, de médicament contre l'urticaire, de remède contre les troubles liés à la reperfusion ischémique, ou encore d'agent anti-inflammatoire. Ces composés sont particulièrement utiles dans le traitement d'occlusions nasales.
Arimura Akinori
Honma Tsunetoshi
Kishino Junji
Ohtani Mitsuaki
Tsuri Tatsuo
Kirby Eades Gale Baker
Shionogi & Co. Ltd.
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