Bicyclic and tricyclic amines as modulators of chemokine...

Details Bicyclic and tricyclic amines as modulators of chemokine... Bicyclic and tricyclic amines as modulators of chemokine...

C - Chemistry, Metallurgy

07

D

C07D 209/62 (2006.01) A61K 31/395 (2006.01) A61P 43/00 (2006.01) C07D 209/52 (2006.01) C07D 451/02 (2006.01) C07D 453/06 (2006.01)

Patent

CA 2386049

The present application describes modulators of CCR3 of formula (I): A-E-NR1- G, or pharmaceutically acceptable salt forms thereof, wherein: A is selected from (a), (b), (c) and (d). G is selected from -C(O)R3, -C(O)NR2R3, -C(O)OR3, - SO2NR2R3, -SO2R3, -C(=S)NR2R3, C(=NR1a)NR2R3, C(=CHCN)NR2R3, C(=CHNO2)NR2R3, C(=C(CN)2)NR2R3, (e), (f) and (g); useful for the prevention of inflammatory diseases such as asthma and other allergic diseases.

La présente invention décrit des modulateurs de CCR de la formule (I): A-E-NR?1¿-G, ou des formes de sels de ceux-ci acceptables sur le plan pharmaceutique, utiles dans la prévention de maladies inflammatoires telles que l'asthme et d'autres maladies allergiques.

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