C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/22 (2006.01) A61K 31/352 (2006.01) A61K 31/353 (2006.01) A61K 31/404 (2006.01) A61K 31/47 (2006.01) A61K 31/4704 (2006.01) A61K 31/4706 (2006.01) A61K 31/517 (2006.01) A61K 31/536 (2006.01) A61P 5/24 (2006.01) A61P 5/26 (2006.01) A61P 5/28 (2006.01) C07D 209/34 (2006.01) C07D 209/96 (2006.01) C07D 215/227 (2006.01) C07D 215/36 (2006.01) C07D 215/38 (2006.01) C07D 215/48 (2006.01) C07D 239/80 (2006.01) C07D 265/18 (2006.01) C07D 265/36 (2006.01) C07D 277/68 (2006.01) C07D 311/08 (2006.01) C07D 311/1
Patent
CA 2384435
The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and antagonists for AR and PR. Also provided are methods of making such compounds and pharmaceutical compositions, as well as critical intermediates used in their synthesis.
La présente invention concerne des composés, des compositions pharmaceutiques et des méthodes de modulation des processus à médiation par récepteur d'androgène (AR) et par récepteur de progestérone (PR). Plus spécifiquement, cette invention concerne des compositions et composés non stéroïdes qui ont des agonistes à affinité et spécificité élevées, des agonistes partiels (par exemple, des activateurs partiels et/ou des activateurs spécifiques de tissus) et des antagonistes pour AR et PR. Cette invention concerne également des méthodes de production de tels composés et compositions pharmaceutiques, ainsi que des intermédiaires cruciaux utilisés dans leur synthèse.
Arjan Van Oeveren Cornelis
Farmer Luc
Hamann Lawrence
Higuchi Robert
Martinborough Esther
Ligand Pharmaceuticals Incorporated
Smart & Biggar
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