Bicyclic anilide spirohydantoin cgrp receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 235/26 (2006.01) A61K 31/4184 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/4427 (2006.01) A61K 31/454 (2006.01) A61K 31/506 (2006.01) A61P 25/06 (2006.01) C07D 235/02 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 413/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 471/10 (2006.01)

Patent

CA 2519475

The present invention is directed to compounds of the formula : that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

L'invention concerne des composés de formule I. Lesdits composés sont des antagonistes des récepteurs du peptide lié au gène de la calcitonine (CGRP) et sont utiles dans le traitement ou la prévention de maladies impliquant le CGRP, telles que la céphalée, la migraine et la céphalée vasculaire de Horton. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi que l'utilisation de ces composés et compositions dans la prévention ou le traitement de maladies impliquant le CGRP.

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