C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/02 (2006.01) A61K 31/44 (2006.01) A61K 31/4965 (2006.01) A61K 31/517 (2006.01) C07D 221/02 (2006.01) C07D 239/00 (2006.01) C07D 241/00 (2006.01) C07D 401/00 (2006.01)
Patent
CA 2579847
The present invention is directed to compounds of Formula (I): (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
La présente invention concerne des composés de formule (I). Dans ladite formule, les variables A1, A2, B, J, K, m, n, R4, R5a, R5b et R5c sont telles que définies dans la description. Lesdits composés sont utiles en tant qu'antagonistes de récepteurs du CGRP et utiles dans le traitement ou la prévention de maladies dans lesquelles le CGRP est impliqué, telles que la céphalée, la migraine et la céphalée vasculaire de Horton. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés ainsi que l'utilisation desdits composés et desdites compositions dans la prévention ou le traitement de telles maladies dans lesquelles le CGRP est impliqué.
Bell Ian M.
Gallicchio Steven N.
Stump Craig A.
Theberge Cory R.
Zartman C. Blair
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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