Bicyclic aromatic compounds useful as inhibitors of...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 31/549 (2006.01) A61P 9/00 (2006.01) A61P 17/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2624468

A compound of formula (I) or a pharmaceutically acceptable salt or prodrug ester thereof: wherein the groups R1-R6, A and Y are as defined in the specification, as inhibitors of (MK2 or MAPKAP kinase-2).

La présente invention concerne une composition réactive pour la libération de composés de vitamine D liés à la protéine liant la vitamine D ainsi qu~un procédé de détection d~un composé de 25-hydroxyvitamine D. Dans ce procédé, le composé 25-hydroxyvitamine D est libéré à partir de la protéine liant la vitamine D en utilisant ce réactif et le mélange ainsi obtenu est analysé. L~invention concerne également l~utilisation du réactif visant à libérer des composés de vitamine D ainsi qu~un kit de détection de la 25-hydroxyvitamine D qui contient, outre les réactifs immunologiques habituels, le réactif de libération de composés de vitamine D.

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