C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01)
Patent
CA 2624329
The invention relates to Bicyclic aryl-sulfonic acid [1 ,3,4]thiadiazol-2-yl- amides of the formula (1) and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta, -alpha and -gamma agonist activity, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.
L'invention concerne des [1,3,4]thiadiazol-2-yl-amides bicycliques de l'acide aryl-sulfonique de formule (I), dans laquelle les radicaux sont tels que définis, ainsi que leurs sels physiologiquement acceptables et dérivés physiologiquement fonctionnels qui présentent une activité agoniste PPAR delta, alpha, et gamma. Cette invention concerne également des procédés de préparation de ces composés. Lesdits composés peuvent servir à traiter et/ou prévenir des troubles du métabolisme des acides gras, des troubles de l'utilisation du glucose, des troubles impliquant la résistance à l'insuline, ainsi que des troubles de démyélinisation et d'autres troubles neurodégénératifs du système nerveux central et périphérique.
Glien Maike
Keil Stefanie
Matter Hans
Schoenafinger Karl
Urmann Matthias
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis
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