Bicyclic benzazepine derivatives as vasopressin antagonists

Details Bicyclic benzazepine derivatives as vasopressin antagonists Bicyclic benzazepine derivatives as vasopressin antagonists

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/044 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2210571

This invention relates to new bicyclic non-peptide vasopressin antagonists of formula (I) which are useful in treating conditions where decreased vasopressin levels are desired, such as in congestive heart failure, in disease conditions with excess renal water reabsorption and in conditions with increased vascular resistance and coronary vasoconstriction.

L'invention porte sur de nouveaux antagonistes bicycliques et non peptidiques de la vasopressine ayant la formule (I) et servant à traiter des états requérant une réduction du taux de vasopressine tels que les insuffisances cardiaques et des maladies caractérisées par un excès de réabsorption d'eau rénale et des états caractérisés par un accroissement de la résistance vasculaire et une vasoconstriction des coronaires.

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