C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/00 (2006.01) A61K 31/357 (2006.01) A61K 31/385 (2006.01) A61K 31/519 (2006.01) A61K 31/70 (2006.01) C07D 498/02 (2006.01)
Patent
CA 2512713
We describe the use of bicyclic carbohydrates for the treatment of hepatitis C virus infections. Different bicyclic carbohydrates were tested in vitro against DNA-viruses, retroviruses and Flaviviridae sp., an important family of human and animal RNA pathogens. Significant activity was observed against the bovine viral diarrhea virus (BVDV). As pestiviruses, such as BVDV, share many similarities with hepatitis C virus (HCV), the bicyclic carbohydrates in general and the preferred bicyclic carbohydrates more specifically are expected to be a treatment for hepatitis C viral infections.
L'invention concerne l'utilisation de carbohydrates bicycliques pour le traitement d'infections dues à l'hépatite C. Des carbohydrates bicycliques différents sont testés in vitro contre des virus ADN, des rétrovirus, et des Flaviviridae, en particulier une famille importante de pathogènes d'ARN humain et animal. L'activité significative a été observée contre le virus de la diarrhée virale bovine (BVDV). Comme les pestivirus, tels que le BVDV, qui présentent de nombreuses similitudes avec le virus de l'hépatite C, les carbohydrates bicycliques, en général, et les carbohydrates bicycliques, en particulier, conviennent à un traitement des infections virales de l'hépatite C.
Balzarini Jan
de Clercq Erik
Neyts Johan
Peys Eric
Ruttens Bart
Borden Ladner Gervais Llp
Kemin Pharma Europe B.v.b.a.
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