Bicyclic carboxamides as 5-ht1a antagonists

Details Bicyclic carboxamides as 5-ht1a antagonists Bicyclic carboxamides as 5-ht1a antagonists

C - Chemistry, Metallurgy

07

D

C07D 451/02 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 209/44 (2006.01) C07D 209/52 (2006.01) C07D 221/22 (2006.01) C07D 223/14 (2006.01) C07D 295/185 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2200443

Bicyclic carboxamides of formula (I) and the pharmaceutically acceptable acid addition salts are 5-HT1A binding agents, particularly 5-HT1A antagonists, and may be used, for example, as anxiolytics. In the formula, X represents -CR2 = CR2- or -(CR2)q-; m represents 0, 1 or 2; n represents 0, 1 or 2; p represents 0, 1, 2 or 3, and q represents 0, 1, 2 or 3; A is an alkylene chain of 1 or 2 carbon atoms optionally substituted by one or more lower alkyl groups; R is a mono or bicyclic aryl or heteroaryl radical; R1 is an aryl or aryl(lower)alkyl radical; and each R2 is independently hydrogen or lower alkyl.

Ces carboxamides bicycliques de la formule (I), ainsi que leurs sels d'addition d'acide, acceptables sur le plan pharmacologique, sont des agents de liaison de 5-HT¿1A?, notamment des antagonistes de 5-HT¿1A?, et peuvent être utilisés, par exemple, en tant anxiolytiques. Dans cette formule, X représente -CR?2¿=CR?2¿- ou -(CR?2¿)¿q?-: m représente 0, 1 ou 2; n représente 0, 1 ou 2; p représente 0, 1, 2 ou 3 et q représente 0, 1, 2 ou 3; A représente une chaîne alkylène possédant 1 ou 2 atome(s) de carbone éventuellement substitué(s) par un ou plusieurs groupe(s) alkyle(s) inférieur(s); R représente un radical aryle ou hétéroaryle, mono ou bicyclique; R?1¿ représente un radical aryle ou aryle-alkyle(inférieur); et chaque R?2¿ représente indépendamment hydrogène ou alkyle inférieur.

Affiliated with

Also associated with

Rating

Bicyclic carboxamides as 5-ht1a antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bicyclic carboxamides as 5-ht1a antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bicyclic carboxamides as 5-ht1a antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1567357