Bicyclic carboxylic acid leukotriene b4 antagonists

Details Bicyclic carboxylic acid leukotriene b4 antagonists Bicyclic carboxylic acid leukotriene b4 antagonists

C - Chemistry, Metallurgy

07

D

C07D 311/22 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/35 (2006.01) C07C 45/46 (2006.01) C07C 45/62 (2006.01) C07C 45/67 (2006.01) C07C 45/71 (2006.01) C07C 45/74 (2006.01) C07C 49/683 (2006.01) C07C 49/747 (2006.01) C07C 49/83 (2006.01) C07C 49/84 (2006.01) C07C 59/90 (2006.01) C07C 69/734 (2006.01) C07C 69/736 (2006.01) C07C 69/738 (2006.01) C07C 235/34 (2006.01) C07C 255/13 (2006.01) C07C 309/66 (2006.01)

Patent

CA 2155202

The invention relates to a compound of formulae: wherein R2, each occurence, independently, is hydroxy, lower alkoxy or NR3R4, wherein R3 and R4, independently, are hydrogen or lower alkyl, and Ph is phenyl and, for the compound of formula C, its geometric isomer, and, when R2 is hydroxy, a pharmaceutically acceptable salt thereof with a base, and an inert carrier. The compounds of formula A, B and C are potent leukotriene B4 antagonists and are therefore useful in the treatment of inflammatory diseases such as psoriasis, rhinitis, chronic obstructive pulmonary disease, inflammatory bowel disease, asthma, acute respiratory distress syndrome, cystic fibrosis, allergy, arthritis such as rheumatoid arthritis, dermatitis such as contact dermatitis, NSAID-induced gastropathy, gout, ischemia/ reperfusion injury, and trauma induced inflammation, such as spinal cord injury.

Les composés des formules A, B et C sont de puissants antagonistes du leukotriène B¿4?. Ils sont donc utiles pour le traitement des affections inflammatoires telles que le psoriasis, la rhinite, la broncho-pneumopathie chronique obstructive, la colopathie inflammatoire, l'asthme, le syndrome de détresse respiratoire aiguë, la mucoviscidose, les allergies, les arthrites telles que l'arthrite rhumatoïde, les dermatoses telles que les dermatoses de contact, les gastropathies induites par les médications anti-inflammatoires non stéroïdiennes, la goutte, l'ischémie ou les lésions consécutives à la perfusion, et les inflammations d'origine traumatique telles que le traumatisme rachidien.

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