Bicyclic compound, production and use thereof

Details Bicyclic compound, production and use thereof Bicyclic compound, production and use thereof

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/395 (2006.01) A61K 31/4178 (2006.01) A61K 31/4196 (2006.01) A61P 31/00 (2006.01) A61P 31/18 (2006.01) A61P 37/06 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2607992

The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: (see formula I) wherein, R1 is a 5- to 6-membered ring group which may be substituted; X1 is a bond or the like; ring A is a 5- to 6- membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X2 is a bivalent group of 1 to 4 atoms; Z1 is a bivalent cyclic ring group or the like; Z2 is a bond or the like; and R2 is an amino group, nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

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