Bicyclic compounds as nr2b receptor antagonists

Details Bicyclic compounds as nr2b receptor antagonists Bicyclic compounds as nr2b receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 235/12 (2006.01) A61K 31/404 (2006.01) A61K 31/416 (2006.01) A61K 31/4184 (2006.01) A61K 31/423 (2006.01) A61K 31/47 (2006.01) A61K 31/517 (2006.01) A61P 25/00 (2006.01) C07D 209/08 (2006.01) C07D 215/12 (2006.01) C07D 215/26 (2006.01) C07D 231/56 (2006.01) C07D 235/08 (2006.01) C07D 239/94 (2006.01) C07D 263/56 (2006.01)

Patent

CA 2521907

This invention provides a compound of the formula (I) wherein R1 and R2 independently represent a hydrogen atom or the like; X represents a covalent bond or the like: A represents a bicyclic, aromatic, saturated or partially unsaturated heterocyclic or carbocyclic group having from 8 to 12 ring atoms; or the like: B represents a phenyl group or a heteroaryl group having from 5 to 6 ring atoms or the like: These compounds are useful for the treatment of disease conditions caused by overactivation of NMDA NR2B receptor such of pain, or the like in mammalian. This invention also provides a pharmaceutical composition comprising the above compound.

L'invention concerne un composé de formule (I), dans laquelle R?1¿ et R?2¿ représentent indépendamment l'un de l'autre un atome d'hydrogène ou similaire, X représente une liaison covalente ou similaire, A représente un groupe hétérocyclique ou carbocyclique bicyclique, aromatique, saturé ou partiellement insaturé avec 8 à 12 atomes cycliques, ou similaires, et B représente un groupe phényle ou un groupe hétéroaryle avec 5 à 6 atomes cycliques, ou similaires. Ces composés sont utiles pour traiter des états pathologiques causés par une suractivation du récepteur NMDA NR2B, tels que des algies ou similaires chez des mammifères. L'invention concerne également une composition pharmaceutique qui contient ce composé.

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