Bicyclic compounds capable of inhibiting tyrosine kinases of...

Details Bicyclic compounds capable of inhibiting tyrosine kinases of... Bicyclic compounds capable of inhibiting tyrosine kinases of...

A - Human Necessities

61

K

A61K 31/54 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) C07D 471/04 (2006.01) C07D 473/34 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2177372

Epidermal growth factor inhibitors of formula (1), where: at least one, and as many as three of A-E are nitrogen, with the remaining atom(s) carbon, or any two contiguous positions in A-E taken together can be a single heteroatom, N, O or S, in which case one of the two remaining atoms must be carbon, and the other can be either carbon or nitrogen; X = O, S, NH or NR7, such that R7 = lower alkyl (1-4 carbon atoms), OH, NH2, lower alkoxy (1-4 carbon atoms) or lower monoalkylamino (1-4 carbon atoms); n = 0, 1, 2.

Sont décrits des inhibiteurs du facteur de croissance de l'épiderme, de formule (1) dans laquelle au moins un, et jusqu'à trois termes parmi A-E sont azote, le ou les atome(s) restant(s) étant du carbone, ou bien deux positions contiguës quelconques dans A-E peuvent former ensemble un seul hétéroatome, N, O ou S, auquel cas l'un des deux atomes restants doit être du carbone, et l'autre peut être soit du carbone soit de l'azote; X = O, S, NH ou bien NR?7¿, de sorte que R?7¿ = alkyle inférieur (1-4 atomes de carbone), O, H, NH¿2?, alcoxy inférieur (1-4 atomes de carbone) ou bien monoalkylamino inférieur (1-4 atomes de carbone); n = 0, 1, 2.

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