C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/048 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 239/70 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2730314
The present invention provides bicyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.
La présente invention porte sur des composés bicycliques, des sels pharmaceutiquement acceptables, des pro-médicaments, des solutés et des hydrates de ceux-ci, ayant une activité antimitotique, une activité de résistance anti-médicament multiple, comme, par exemple, une inhibition de la glycoprotéine P, et une activité anti-tumorale, et qui inhibe les cellules tumorales sensibles et résistantes au paclitaxel. L'invention porte également sur des procédés d'utilisation de ces composés pour traiter des cellules tumorales et inhiber la mitose de cellules cancéreuses.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Duquesne University Of The Holy Spirit
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