C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/58 (2006.01) A61K 31/4184 (2006.01) A61K 31/423 (2006.01) A61P 25/16 (2006.01) C07D 235/26 (2006.01)
Patent
CA 2407164
Described are heterocycle-substituted cyclohexylamines of formula (I), and their pharmaceutically acceptable salts thereof. The compounds of formula (I) are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, cerebral ischemia, cardiac arrest, stroke, and Parkinson's disease.
La présente invention concerne des cyclohexylamines à hétérocycliques substitués représentés par la formule (I), et les sels pharmaceutiquement acceptables de ceux-ci. Ces composés représentés par la formule (I) sont des antagonistes des complexes canalaires du récepteur NMDA (N-méthyl D-aspartate) qui conviennent pour traiter les troubles cérébro-vasculaires tels que, par exemple, l'ischémie cérébrale, l'arrêt cardiaque, l'ictus et la maladie de Parkinson.
Deorazio Russell Joseph
Nikam Sham Shridhar
Scott Ian Leslie
Sherer Brian Alan
Wise Lawrence David
Sim & Mcburney
Warner-Lambert Company
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