C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2610491
The invention relates to substantially pure compounds of the formula (1): and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, R5, and X are as defined herein, and wherein the compound of formula (1) optionally further comprises a hydroxy substituent, an O- glucuronic acid, or an N->O (N-oxide) moiety. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders that contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).
La présente invention a trait à des composés sensiblement purs de formule 1 dans laquelle R1, R2, R3, R5, et X sont tels que définis dans la description, et dans laquelle le composé de formule 1 comporte éventuellement également un substituant hydroxy, un acide O-glucoronique, ou un groupe fonctionnel N->O (N-oxyde) et à leurs sels. prodrogues et solvates pharmaceutiquement acceptables. La présente invention a également trait à des procédés de traitement de croissance cellulaire anormale chez des mammifères par l'administration des composés de formule 1 et à des compositions pharmaceutiques pour le traitement de tels troubles qui contiennent des composés de formule 1. L'invention a trait en outre à des procédés de préparation des composés de formule 1.
Bhattacharya Samit Kumar
Prakash Chandra Aggarwal
Pfizer Products Inc.
Smart & Biggar
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