Bicyclic derivatives of azabicyclic carboxamides,...

Details Bicyclic derivatives of azabicyclic carboxamides,... Bicyclic derivatives of azabicyclic carboxamides,...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/404 (2006.01) A61K 31/4188 (2006.01) A61K 31/429 (2006.01) A61K 31/4365 (2006.01) A61K 31/437 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61P 3/00 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) C07D 207/325 (2006.01) C07D 213/72 (2006.01) C07D 215/38 (2006.01) C07D 233/88 (2006.01) C07D 277/42 (2006.01) C07D 471/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2712914

The invention relates to the compounds of general formula (I) in which X1, X2, X3 and X4 are, independently of one another, a nitrogen atom or a C-Ri group; W is an oxygen or sulphur atom; n is equal to 0, 1, 2 or 3; Y is an optionally substituted aryl or heteroaryl; A is the group of formula: (II), Z1, Z2, Z3 and Z4 are, independently of one another, a nitrogen atom or a C-R2 group; Ra and Rb form, together with the carbon atoms which bear them, either a partially unsaturated cycloalkyl, or an aryl; or a heterocycle, or a heteroaryl with 5 to 7 ring members comprising from one to three heteroatoms selected from O, S or N; it being possible for this cycloalkyl, this aryl, this heterocycle or this heteroaryl to be substituted with one or more substituents R3; in the form of a base or of an addition salt with an acid, and also in the form of a hydrate or of a solvate. Process for the preparation thereof and therapeutic use.

indépendamment l'un de l'autre, un atome d'azote ou un groupe C-Ri; W représente un atome d'oxygène ou de soufre; n est égal à 0, 1, 2 ou 3; Y représente un aryle ou un hétéroaryle éventaellement substitué; A représente le groupe de formule :(II) Z1, Z2, Z3 et Z4 représentent, indépendamment l'un de l'autre, un atome d'azote, ou un groupe C-R2; Ra et Rb forment ensemble avec les atomes de carbone qui les portent, soit un cycloalkyle partiellement insataré, soit un aryle; soit un hétérocycle, soit un hétéroaryle de 5 à 7 chaînons comprenant de un à trois hétéroatomes choisi parmi O, S ou N; ce cycloalkyle, cet aryle, cet hétérocycle ou cet hétéroaryle pouvant être substitués par un ou plusieurs substituants R3; à l'état de base ou de sel d'addition à un acide, ainsi qu'à l'état d'hydrate ou de solvate. Procédé de préparation et application en thérapeutique.

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