Bicyclic fibrinogen antagonists

Details Bicyclic fibrinogen antagonists Bicyclic fibrinogen antagonists

C - Chemistry, Metallurgy

07

D

C07D 243/10 (2006.01) A61K 31/435 (2006.01) A61K 31/55 (2006.01) C07C 319/14 (2006.01) C07D 211/18 (2006.01) C07D 211/34 (2006.01) C07D 211/70 (2006.01) C07D 213/24 (2006.01) C07D 223/16 (2006.01) C07D 243/04 (2006.01) C07D 243/14 (2006.01) C07D 243/24 (2006.01) C07D 267/14 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 453/02 (2006.01)

Patent

CA 2152631

This invention relates to compounds of formulae (I), (II), (III), wherein A1 is O, S, N-R1 or CHR1; A4 is N-R4 or CHR4; R2 is a sidechain containing an acid or ester group; R1, R4 and R5 are substituents such as H, alkyl and aryl alkyl, and R6 is a sidechain containing a nitrogen group; and pharmaceutically acceptable salts thereof, which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.

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