Bicyclic heteroaromatic compounds

Details Bicyclic heteroaromatic compounds Bicyclic heteroaromatic compounds

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/519 (2006.01) A61P 5/24 (2006.01) C07D 215/48 (2006.01) C07D 221/00 (2006.01) C07D 239/00 (2006.01) C07D 239/78 (2006.01) C07D 333/00 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2422054

A bicyclic heteroaromatic compound according to general formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is (3-8C)cycloalkyl, (2- 7C)heterocycloalkyl, (6-14C)aryl or (4-13C)heteroaryl; all optionally substituted with one or more substituents; R2 is (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, (6-14C)aryl or (4-13C)heteroaryl; R3 is (1-8C)alkyl, (3- 8C)cycloalkyl, (2-7C)heterocycloalkyl, (6-14C)aryl or (4-13C)heteroaryl; Y is CH or N; Z is NH2 or OH; A is S, N(H), N(R), O or a bond and B is N(H), O or a bond; X1-X2 is C=C, C(O)-NH, NH-C(O), C(O)-O, O-C(O), C=N, N=C or S or O. The compounds of the invention can be used in fertility regulation therapies.

La présente invention concerne un composé hétéroaromatique bicyclique représenté par la formule générale (I) ou l'un de ses sels pharmaceutiquement admis. Dans cette formule, R?1¿ est C¿3?-C¿8? cycloalkyle, C¿2?-C¿7? hétérocycloalkyle, C¿6?-C¿14? aryle ou C¿4?-C¿13? hétéroaryle, tous pouvant être substitués par un ou plusieurs substituants. R?2¿ est C¿1?-C¿4? alkyle, C¿2?-C¿4? alcényle, C¿2?-C¿4? alkynyle, C¿6?-C¿14? aryle ou C¿4?-C¿13? hétéroaryle. R?3¿ est C¿1?-C¿8? alkyle, C¿3?-C¿8? cycloalkyle, C¿2?-C¿7? hétérocycloalkyle, C¿6?-C¿14? aryle ou C¿4?-C¿13? hétéroaryle. Y est CH ou N. Z est NH¿2? ou OH. A est S, N(H), N(R), O ou une liaison, et B est N(H), O ou une liaison. X1-X2 est C=C, C(O)-NH, NH-C(O), C(O)-O, O-C(O), C=N, N=C ou S ou O. Les composés de l'invention conviennent pour le thérapies concernant la régulation de la fertilité.

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