Bicyclic heteroaromatic compounds as inhibitors of...

Details Bicyclic heteroaromatic compounds as inhibitors of... Bicyclic heteroaromatic compounds as inhibitors of...

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) C07D 473/32 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2693290

Bicyclic heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; liver steatosis; and non-alcoholic steatohepatitis.

Composés hétéroaromatiques bicycliques de formule structurelle I, inhibiteurs de la stéaroyl-coenzyme A delta-9 désaturase (SCD). Les composés de la présente invention sont utiles pour la prévention et le traitement d'états liés à une synthèse et un métabolisme lipidiques anormaux, y compris la maladie cardio-vasculaire, l'athérosclérose, l'obésité, le diabète, la maladie neurologique, le syndrome métabolique, l'insulinorésistance, la stéatose hépatique et la stéatohépatite non alcoolique.

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