Bicyclic heteroaromatic compounds as kinase inhibitors

Details Bicyclic heteroaromatic compounds as kinase inhibitors Bicyclic heteroaromatic compounds as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 19/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2500844

A series of 5-6 fused ring bicyclic heteroaromatic derivatives, based in particular on the 5-oxo-4,5-dihydro-1H-pyrrolo[3,2-b]pyridine ring system, being inhibitors of p38 kinase, are accordingly of use in medicine, for example in the treatment and/or prevention of immune or inflammatory disorders.

L'invention concerne une série de dérivés hétéroaromatiques bicycliques à 5-6 cycles fusionnés, basés en particulier sur le système d'anneau 5-oxo-4,5-dihydro-1<I>H</I>-pyrrolo[3,2-b]pyridine. Les dérivés sont des inhibiteurs de la kinase p38 et sont utilisés en médecine, par exemple dans le traitement et/ou la prévention de troubles immunitaires ou inflammatoires.

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