C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07C 217/86 (2006.01) C07C 317/36 (2006.01)
Patent
CA 2260058
Substituted heteroaromatic compounds, and in particular substituted bicyclic heteroaromatic compounds in which one ring is a pyridine or pyrimidine of formula (I) are protein tyrosine kinase inhibitors. The compounds are described as are methods for their preparation, pharmaceutical compositions including such compounds and their use in medicine, for example in the treatment of cancer and psoriasis.
L'invention a trait à des composés hétéroaromatiques substitués, et en particulier des composés hétéroaromatiques bicycliques substitués, dans lesquels un noyau est une pyridine ou une pyrimidine de la formule (I), qui sont des inhibiteurs de la protéine tyrosine kinase. Des composés sont décrits, ainsi que leurs méthodes de préparation, des compositions pharmaceutiques contenant de tels composés et leur utilisation médicinale, par exemple dans le traitement du cancer ou du psoriasis.
Carter Malcolm Clive
Cockerill George Stuart
Guntrip Stephen Barry
Smith Kathryn Jane
Glaxo Group Limited
Swabey Ogilvy Renault
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