Bicyclic heteroaryl compounds and their use as kinase...

Details Bicyclic heteroaryl compounds and their use as kinase... Bicyclic heteroaryl compounds and their use as kinase...

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4436 (2006.01) A61K 31/5025 (2006.01) A61P 35/00 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2693232

Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

L'invention porte sur des composés inhibiteurs de la phosphatidylinositol (PI) 3-kinase, sur leurs sels acceptables du point de vue pharmaceutique et sur des promédicaments de ceux-ci ; sur des compositions des nouveaux composés, soit individuellement, soit en combinaison avec au moins un agent thérapeutique additionnel, avec un support acceptable du point de vue pharmaceutique ; sur les utilisations des nouveaux composés, soit individuellement, soit en combinaison avec au moins un agent thérapeutique additionnel, dans la prophylaxie ou le traitement de maladies prolifératives caractérisées par l'activité anormale de facteurs de croissance, de protéine sérine/thréonine kinases et de phospholipide kinases.

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