C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2650976
The invention pertains to tricyclic heteraaryi compounds that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds which are selective inhibitors of PDE 10. The invention further relates to pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders. The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom.
L'invention concerne des composés d'hétéroaryle bicyclique servant d'inhibiteurs efficaces de la phosphodiestérase (PDE). L'invention concerne également des composés qui sont des inhibiteurs sélectifs de la PDE 10. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés dans des méthodes destinées au traitement de certains troubles du système nerveux central (SNC) et d'autres troubles. L'invention concerne également des méthodes destinées au traitement de troubles neurodégénératifs et psychiatriques, tels que la psychose et des troubles ayant comme symptôme un déficit de la cognition.
Hoover Dennis Jay
Verhoest Patrick Robert
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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