Bicyclic heteroaryl compounds as pde10 inhibitors

Details Bicyclic heteroaryl compounds as pde10 inhibitors Bicyclic heteroaryl compounds as pde10 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4164 (2006.01) A61P 25/00 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 471/06 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2636264

The invention pertains to bicyclic heteroaryl compounds that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds which are selective inhibitors of PDE-10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders. The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom.

L'invention concerne des composés d'hétéroaryles bicycliques qui sont des inhibiteurs efficaces des phosphodiestérases (PDE). L'invention concerne également des composés qui sont des inhibiteurs sélectifs de la PDE-10. L'invention concerne en outre des intermédiaires pour la préparation de ces composés ; des compositions pharmaceutiques comprenant ces composés ; et l'utilisation de ces composés dans des procédés de traitement de certains troubles du système nerveux central (CNS) ou autres. L'invention concerne également des procédés de traitement de troubles neurodégénératifs et psychiatriques, par exemple la psychose et des troubles ayant comme symptôme un déficit de la cognition.

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