C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) C07D 209/30 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2583428
Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and stractural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
La présente invention a trait à des composés qui présentent une activité sur la PDE4. L'invention a également trait à des structures cristallines de la PDE4B déterminés à l'aide de la cristallographie aux rayons X, l'utilisation de cristaux et d'information structurelle de la PDE4B pour l'identification de squelettes moléculaires, pour le développement de ligands de liaison et de modulation de la PDE4B, et pour l'identification de ligands améliorés basés sur des ligands connus.
Artis Dean R.
Bremer Ryan E.
Cho Hanna
Gillette Samuel J.
Ibrahim Prabha N.
Borden Ladner Gervais Llp
Plexxikon Inc.
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