C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 498/04 (2006.01) A61K 31/519 (2006.01) A61P 31/18 (2006.01) C07D 239/00 (2006.01) C07D 263/00 (2006.01) C07D 265/00 (2006.01) C07D 267/00 (2006.01)
Patent
CA 2568356
The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
La présente invention concerne une série de composés de pyrimidinone bicycliques cycliques de formule (I) qui inhibent l'intégrase de VIH et qui empêchent une intégration virale dans l'ADN humain. Ces composés sont par conséquent utilisés pour traiter une infection à VIH et le SIDA. Cette invention concerne également des compositions pharmaceutiques et des procédés pour traiter les personnes infectées par le VIH.
Banville Jacques
Beaulieu Francis
Connolly Timothy P.
Krystal Mark R.
Matiskella John D.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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