Bicyclic heterocycles as mek kinase inhibitors

Details Bicyclic heterocycles as mek kinase inhibitors Bicyclic heterocycles as mek kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 231/56 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01) C07D 275/04 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2727250

The invention relates to bicyclic heterocycles of formulae I and II with anti- cancer and/or anti-inflammatory activity and more specifically with MEK kinase inhibitory activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth, treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for m vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

L'invention concerne des hétérocycles bicycliques des formules I et II avec une activité anticancéreuse et/ou anti-inflammatoire, et plus particulièrement une activité d'inhibition de MEK kinase. L'invention concerne des compositions et des procédés utiles pour inhiber une croissance cellulaire anormale, pour traiter un trouble hyper prolifératif, ou pour traiter une maladie inflammatoire chez un mammifère. L'invention concerne également des procédés d'utilisation des composés pour un diagnostic ou un traitement in vitro, in situ et in vivo, de cellules de mammifère ou d'états pathologiques associés.

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